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- 產(chǎn)品名稱： GW6471
- 產(chǎn)品貨號(hào)： CST8486
- 貨期： 現(xiàn)貨
- 價(jià)格與訂購(gòu)： 497
- 數(shù)量：
庫(kù)存： 5
- 規(guī)格： 5mg
- 產(chǎn)品信息
- 如何訂購(gòu)
產(chǎn)品描述
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.
體外活性
A specific PPARα antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in VHL(+) and VHL(-) RCC cell lines (786-O and Caki-1) associated with attenuation of the cell cycle regulatory proteins c-Myc, Cyclin D1, and CDK4;?this data was confirmed as specific to PPARα antagonism by siRNA methods.
別名
GW 6471
分子量
619.67
分子式
C35H36F3N3O4icon
CAS No
880635-03-0
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 120 mg/mL (193.65 mM), Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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參考文獻(xiàn)
1. Abu Aboud O, et al. Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysisinhibition in kidney cancer cells. PLoS One. 2013 Aug 7;8(8):e71115.
2. Xu HE, et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature. 2002 Feb 14;415(6873):813-7.
3. Abu Aboud O, et al. PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth. Am J Physiol Cell Physiol. 2015 Jun 1;308(11):C890-8.
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Note
For research use only.
上一篇 Pirinixic Acid
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Amily
