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產(chǎn)品名稱： Pomiferin 橙桑黃酮
產(chǎn)品貨號(hào)： CSN4315
貨期： 現(xiàn)貨
價(jià)格與訂購： 2400
數(shù)量：

庫存： 5
規(guī)格： 5mg

產(chǎn)品信息
如何訂購

生物活性

Pomiferin (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 μM).

IC50 & Target

HDAC：1.05 μM (IC₅₀)
mTOR：6.2 μM (IC₅₀)

體外研究(In Vitro)

Pomiferin is an potential inhibitor of HDAC, with an IC50 of 1.05 μM. Pomiferin shows cytotoxic effects on human tumor cell lines, with GI50s of 1.32 ± 0.02 μM (HCT-15 cells), 2.92 ± 0.09 μM (MDA-MB-231 cells), 3.18 ± 0.05 μM (ACHN cells), 3.34 ± 0.11 μM (LOX-IMVI cells), 3.95 ± 0.05 μM (PC-3 cells), 5.14 ± 0.06 μM (NCI-H23 cells), and 123 μM (Hepatocyte cells)[1]. Pomiferin is a highly specific mTOR inhibitor, with an IC50 of 6.2 μM. Pomiferin triacetate only affects two PI3Kα mutants, E542K and E545K. Pomiferin triacetate (0.3125-20 μM) stabilizes Pdcd4 from TPA-induced degradation in HEK293 cells. Pomiferin triacetate (20 μM) inhibits IGF-1-induced signaling downstream of Akt activation[2].

體內(nèi)研究(In Vivo)

Pomiferin (5, 10 and 20 mg/kg, p.o.) shows protective effects on the treatment of reperfusion injury. Pomiferin also increases SOD activities and total antioxidative capacity, and decreases malondialdehyde in rats[3].

分子量

420.45icon

性狀

固體

Formula

C25H24O6

CAS 號(hào)

572-03-2

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中文名稱

橙桑黃酮

結(jié)構(gòu)分類

PhenolsPolyphenols

初始來源

植物?？瞥壬?/div>

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CAS 號(hào)

1955-26-6

儲(chǔ)存方式

Powder-20°C 3 years，4°C 2 years；In solvent -80°C 6 months -20°C 1 month

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參考文獻(xiàn)

[1]. Son IH, et al. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4753-5. [Content Brief]

[2]. Bajer MM, et al. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol. 2014 Apr 1;88(3):313-21. [Content Brief]

[3]. Barto?íková L, et al. Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats. Interdiscip Toxicol. 2010 Jun;3(2):76-81. [Content Brief]

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純度

97.36%

Note

For research use only .

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