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- 產(chǎn)品名稱(chēng)： Anti-DNA-RNA Hybrid Antibody(S9.6)
- 產(chǎn)品貨號(hào)： CSK60001
- 貨期： 現(xiàn)貨
- 價(jià)格與訂購(gòu)： 2480
- 數(shù)量：
庫(kù)存： 5
- 規(guī)格： 100μg
- 產(chǎn)品信息
- 如何訂購(gòu)
Description
DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. A locus forming an DNA:RNA creates a double-stranded A/B intermediate conformation, with a second target for single-stranded nucleic acid binding proteins on the complementary, displaced DNA strand. They are shown to be resistant to the activity of DNA methyltransferases. The formation of DNA:RNA hybrids has been associated with a number of neurological diseases. Mutations in the DNA:RNA helicase senataxin (SETX) are implicated in the dominant juvenile form of amyotrophic lateral sclerosis type 4 and a recessive form of ataxia oculomotor apraxia type 2.
Catalog No.
CSK60001
Host species
mouse
Tested applications
CHIP, ChIP-seq, DB, EMSA, FISH, ICC, IP, SPR, IF
Species reactivity
General
Form
liquid
Storage buffer
0.01M PBS, pH 7.4.
Concentration
0.74 mg/ml
Purity
>95%
Clonality
Monoclonal
Isotype
IgG2a, kappa
Applications
CHIP, ChIP-seq, DB, EMSA, FISH, ICC, IP, SPR, IF
Purification
Protein A or G purified from cell culture supernatant.
Endotoxin level
Please contact with the lab for this information.
Expression system
Mammalian cells
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
Alternative Names
DNA-RNA Hybrid
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Note
For research use only. Not suitable for clinical or therapeutic use.
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產(chǎn)品銷(xiāo)售：
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郵 編：
Amily
